John Krystal, MD
Cards
Titles
Co-Director, Yale Center for Clinical Investigation; Chair, Psychiatry; Physician-in-Chief of Psychiatry, Yale New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD
Publications Overview
- 910 Publications
- 75,164 Citations
- 198 Yale Co-Authors
Administrative Support
Titles
Co-Director, Yale Center for Clinical Investigation; Chair, Psychiatry; Physician-in-Chief of Psychiatry, Yale New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD
Publications Overview
- 910 Publications
- 75,164 Citations
- 198 Yale Co-Authors
Administrative Support
Titles
Co-Director, Yale Center for Clinical Investigation; Chair, Psychiatry; Physician-in-Chief of Psychiatry, Yale New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD
Publications Overview
- 910 Publications
- 75,164 Citations
- 198 Yale Co-Authors
Administrative Support
About
Titles
Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology
Co-Director, Yale Center for Clinical Investigation; Chair, Psychiatry; Physician-in-Chief of Psychiatry, Yale New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSDBiography
Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, the Karolinska Institutet, and the U.S. Department of Veterans Affairs.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, the National Institute of Mental Health (NIMH) Advisory Council, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Forum on Neuroscience and Nervous System Disorders (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, and he edits the journal, Biological Psychiatry (impact factor: 13.382).
Appointments
Psychiatry
ChairDualPsychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondaryDepartment of Psychology
ProfessorSecondary
Other Departments & Organizations
- Division of Neurocognition, Neurocomputation & Neurogenetics
- Adult Psychiatry
- Center for the Translational Neuroscience of Alcohol
- Clinical Neuroscience Research Unit
- Dean's Workshops
- Department of Psychology
- Diabetes Research Center
- Interdepartmental Neuroscience Program
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Yale Center for Clinical Investigation (YCCI)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Ventures
- Yale-Drug use, Addiction, and HIV prevention Research Scholars (DAHRS)
Education & Training
- Residency
- Yale University School of Medicine (1988)
- MD
- Yale University (1984)
- BA
- University of Chicago, Behavioral Sciences (1980)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-6952-1726
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Deepak Cyril Dsouza, MBBS, MD
Joel Gelernter, MD
Ilan Harpaz-Rotem, PhD, ABPP
Ismene Petrakis, MD
Chadi Abdallah, MD
Edward Belk Perry Jr, MD, MHS
Schizophrenia
Stress Disorders, Post-Traumatic
Alcoholism
Veterans
Psychiatry
Neuroimaging
Publications
Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor
Averill C, Averill L, Akiki T, Fouda S, Krystal J, Abdallah C. Findings of PTSD-specific deficits in default mode network strength following a mild experimental stressor. NPP—Digital Psychiatry And Neuroscience 2024, 2: 9. PMID: 38919723, PMCID: PMC11197271, DOI: 10.1038/s44277-024-00011-y.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderMajor depressive disorderConnectivity deficitsConnection strengthPrimary diagnosis of posttraumatic stress disorderExperimental stressorsDiagnosis of posttraumatic stress disorderResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingVentromedial prefrontal cortexDMN connectivity strengthStress-induced reductionEffect of groupDMN alterationsPrefrontal cortexDepressive disorderDMN connectivityStressor taskStress disorderBrain region(sAcute stressorFunctional connectivityDMNExploratory analysisDeficitsPost-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans
Kraguljac N, Bruns D, Appelbaum P, Botello E, King V, Remiszewski N, Widge A, Alpert J, Carpenter L, Grzenda A, Krystal J, McDonald W, Nemeroff C. Post-Roe v Wade psychiatry: legal, clinical, and ethical challenges in psychiatry under abortion bans. The Lancet Psychiatry 2024 PMID: 38795722, DOI: 10.1016/s2215-0366(24)00096-8.Peer-Reviewed Original ResearchAltmetricConceptsRoe v WadeAbortion banDobbs v Jackson Women's Health OrganizationUS Supreme Court rulingLiberalization of abortion lawsSupreme Court rulingPsychiatric careAbortion careConstitutional rightsCourt rulingsLegal landscapeAbortion lawsPsychiatric groundsPatient autonomyEthical conductBanEthical challengesPublic health consequencesEthical responsibilityPsychiatristsMedical necessityPracticing psychiatristsAbortionTopical overviewPersonal viewThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original ResearchMulti-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder
Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.Peer-Reviewed Original ResearchHuman Brain State Dynamics Reflect Individual Neuro-Phenotypes
Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human Brain State Dynamics Reflect Individual Neuro-Phenotypes. Biological Psychiatry 2024, 95: s53. DOI: 10.1016/j.biopsych.2024.02.133.Peer-Reviewed Original ResearchKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminProblem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics
Na P, Petrakis I, Krystal J, Pietrzak R. Problem Opioid Use Among US Military Veterans: Prevalence, Correlates, and Psychiatric Characteristics. Journal Of Addiction Medicine 2024, 18: 313-318. PMID: 38498625, PMCID: PMC11150085, DOI: 10.1097/adm.0000000000001286.Peer-Reviewed Original ResearchConceptsInstrumental activities of daily livingInstrumental activities of daily living disabilityLifetime suicide attemptsProblem opioid useUS military veteransUS veteransPsychiatric characteristicsSuicide attemptsMilitary veteransAssociated with black race/ethnicityActivities of daily livingNational Health and ResilienceLifetime alcohol use disorderMental health morbidityPosttraumatic stress disorderMental health disordersAlcohol use disorderNon-Hispanic race/ethnicityMultivariate logistic regression modelNationally representative sampleOpioid useLogistic regression modelsInstrumental activitiesHealth morbidityDaily livingRecent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023
Havlik J, Wahid S, Teopiz K, McIntyre R, Krystal J, Rhee T. Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023. Current Psychiatry Reports 2024, 26: 176-213. PMID: 38386251, DOI: 10.1007/s11920-024-01494-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTreatment of treatment-resistant depressionTreatment-resistant depressionMedication discontinuation ratesTranscranial magnetic stimulationElectroconvulsive therapyPsychiatric approachApproach to treatmentAdjunctive pharmacotherapyIntervention approachesAdjunctive treatmentDiscontinuation ratesMagnetic stimulationGeneralizability resultsDepressionPharmacotherapyInclusion criteriaAntipsychoticsPsychotherapyNarrative reviewKetamine/esketamineSide effectsStudy inclusion criteriaRecent FindingsRecent evidenceDisordersBuprenorphineFrontal norepinephrine represents a threat prediction error under uncertainty
Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal norepinephrine represents a threat prediction error under uncertainty. Biological Psychiatry 2024 PMID: 38316333, DOI: 10.1016/j.biopsych.2024.01.025.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPrediction error signalsResponses to conditioned stimuliThreat prediction errorsReinforcement learning modelThreat learningAnticipation of dangerAversive learningMemory strengthConditioned stimulusNoradrenergic signalingDefensive behaviorError signalPrediction errorAuditory stimuliTask structureNorepinephrine releaseNorepinephrineLearning modelsPredictive signalsStimuliFootshockDopamineLearningRewardErrorIllusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
Clinical Trials
Current Trials
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HIC ID2000033404RoleSub InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsAlcohol Interaction Study
HIC ID2000030342RoleSub InvestigatorPrimary Completion Date01/31/2023Recruiting ParticipantsGenderBothAge21 years - 65 yearsStudying the Adult Brain
HIC ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsAMPA Receptor Components of the Anti-Depressant Ketamine Response
HIC ID2000021345RolePrincipal InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 yearsEfficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
HIC ID2000020355RoleSub InvestigatorPrimary Completion Date07/31/2023Recruiting ParticipantsGenderBothAge21 years - 55 years
Academic Achievements and Community Involvement
activity Member
Peer Review Groups and Grant Study SectionsNIMHDetails2016 - PresentDescriptionNIMH National Mental Health Advisory Councilactivity Co-Director
Professional OrganizationsNeuroscience Forum, National Academies of Sciences, Engineering, and MedicineDetails07/01/2018 - PresentDescriptionCo-Directorhonor Colvin Prize for Outstanding Achievement in Mood Disorders Research
International AwardBrain and Behavior Research FoundationDetails11/01/2019United Stateshonor Ulf van Euler Memorial Lecturer
International AwardKarolinska InstituteDetails10/18/2019Swedenhonor Edward H. Ahrens, Jr., Distinguished Investigator Award
National AwardAssociation for Clinical and Translational ScienceDetails03/07/2019United States
Clinical Care
Overview
John Krystal, MD, is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).
Clinical Specialties
Fact Sheets
Depression
Learn More on Yale Medicine
Board Certifications
Psychiatry
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 1991
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News
- July 19, 2024
Yale Scientists Aim to Achieve Better Understanding of Molecular Effects of Alcohol Use Disorder on Brain
- July 16, 2024
YNHH Psychiatry Ranked 6th Nationally in U.S. News & World Report 'America's Best Hospitals' Survey
- June 21, 2024
Department of Psychiatry Honors Residents, Fellows, Faculty, Staff at 2024 Annual Commencement Ceremonies
- June 05, 2024Source: New Haven Independent
Yale Panel Welcomes 'Psychedelic Renaissance'
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